Clinical Findings:

Acute toxemia:

• Depression, anorexia, muscular weakness
• Calves donot suck voluntarily and may not have suckling reflex
• Scanty feces or low volume diarrhoea is present
• Increased heart rate, weak pulse
• Fever is common in early stages but later temperature may be normal or sub-normal.
• Animals collapses and death occurs with coma or with convulsions.

Endotoxemia:

• Severe peripheral vasodilatation with consequent fall in blood pressure
• Pallor of mucosa
• Hypothermia, tachycardia
• Pulse of small amplitude
• Muscle weakness
• Hyperthermia followed by hypothermia
• Decreased systemic blood pressure
• Cool skin and extremities
• Diarrhoea
• Congested mucus membrane with increased CRT
• Muscle weakness leading to recumbency
• Renal failure characterized by anuria
• If DIC develops, it is characterized by petechial and ecchymotic hemorrhages and sclerae with tendency to bleed from venipuncture sites.

Chronic toxemia:

• Lethargy
• Separation from rest of group
• Failure to grow or produce
• Emaciation