Azoturia:

Syn: Monday morning sickness, Paralytic Myoglobinuria, Tying Up, Equine Exertional Rhabdomyolysis

• It is metabolic disease of horse occurring during exercise after a period of rest on full ration.
• It is characterized by muscle degeneration, Myoglobinuria, stiff gait, lameness, swelling, and hardening of skeletal muscles

Etiology:

• Overloading of carbohydrate, excessive production of lactic acid
• B₁ deficiency
• E and Se deficiency

Pathogenesis:

Horses on full ration during rest period results in excess storage of glycogen in muscle.

During exercise, after a period of rest, muscle glycogen is rapidly converted to lactic acid due to hypoxia

Lactic acid cannot be cleared by blood and gets accumulated in muscle

Lactic acid produces toxic effect on muscle causing coagulation and degeneration

Muscle becomes hard, stiff, swollen and Myoglobinuria occurs.