Clinical Signs:

• Signs develop 15-60 minutes after beginning of exercise.
• Profuse sweating, stiffness in gait, reluctant to move
• Horse assumes a dog-sitting position followed by lateral Recumbency
• Accelerated weak pulse, rapid respiration, and temperature may rise upto 40.5°C
• Hardboard like muscles- particularly of hindlegs (gluteal and quadriceps)
• Horse voids dark-red brown urine (Hburia).

Treatment:

• Avoid further exercise, give rest to animal.
• Supportive treatment; Massage of limbs by hot application
• IV injection of large quantities of fluids and electrolytes to maintain urine flow.
• Dexamethasone IV in large doses @2-5 mg IV or IM
• Thiamin (Vitamin B₁) @ 0.5-1 gm IM or IV
• NSAID; Flunixin @1ml/50 kg, b.wt., OD. It may be repeated upto 5 days
• Avil or Phenergan @ 10-15 ml, IV or IM
• E + Selenium mixture injection @1ml/50 kg, b.wt. It is repeated at 5-10 days’ interval.