Post-Parturient Hemoglobinuria (PPH):

Syn: Hypophosphatemia, Metabolic or Nutritional Hemoglobinuria

• It is metabolic disease of high producing dairy cows and buffaloes characterized by intravascular hemolysis, hemoglobinuria and anemia.

Etiology:

• Deficiency of P in diet
  • Soil deficient in P
  • Hay, straws and plant rich in oxalate are naturally deficient in P
  • Drought, stress reduces P content in forage
• Impaired absorption of P
  • Excess Ca and Fe in diet
  • Vitamin D deficiency
  • Improper Ca: P ratio
• Increased requirement of P
  • Heavy loss through milk
  • For development of fetuses
• Feeding of cruciferous plants like cabbage, turnip, kales, rape, rye
• Forage low in Cu, Se and Mo
• Plant rich in saponin, oxalate

Epidemiology:

• Cattle and buffaloes are more susceptible. Buffaloes are more susceptible than cattle
• More common during 3^rd lactation-6^th lactation, 5-10 years of age
• Mostly occur between 2-4 weeks after calving
• Advanced pregnant animal is more prone
• Heavy milker, cold weather and malnutrition.