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Learn Principles and Practices and Animal Breeding with Rahul

Transgenic animal

  • A transgenic animal is one whose genome has been changed to carry genes from other species.
  • They are produced for the following reasons:

a) Some transgenic animals are produced for specific economic traits. For example, transgenic cattle were created to produce milk containing particular human proteins, which may help in the treatment of human emphysema.

b) Other transgenic animals are produced as disease models (animals genetically manipulated to exhibit disease symptoms so that effective treatment can be studied).

 

How are transgenic animals produced?

The insertion of a foreign gene (transgene) into an animal is successful only if the gene is inherited by offspring. The success rate for transgenesis is very low and successful transgenic animals need to be cloned or mated.

To date, there are three basic methods of producing transgenic animals:

  • DNA microinjection
  • Retrovirus-mediated gene transfer
  • Embryonic stem cell-mediated gene transfer.
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