History of chemotherapy:
It is mainly divided into three period:
- Before Ehrlich’s period (till 1900):
- Usage of chaulmogra oil by Hindu in leprosy.
- Cinchona bark for fever
- Mouldy curd by Chinese on boils
- Mercury by paracelsus for syphilis.
- Ehrlich’s period (1900-1930):
- Organometallic dye for treatment for care.
- After Ehrlich’s period (1930 to till):
- Discovery of sulphonamide.
Timeline history of chemotherapy development:
- Paul Ehrilich developed chemotherapy animal model
- Discovery of Arsphenamine
- Alexander Fleming discovered Penicillin
- Gerhard Domagk- Sulfonamidochrysoidine
- Nitrogen mustard in lymphomas
- Waksman et.al, discovered streptomycin
- Antifolates
- Thiopurines
- 5-fluorouracil
- Methotrexate
- Antitumour antibiotics
- Nalidixic acid
- Vinca alkaloids
- Imatinib
- Monoclonal antibody approved for the treatment of tumour
- Tyrosine kinase inhibitors
2007- Target specific screens