Course Content
History of genetics
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Extra-nuclear inheritance – genes in organelles, maternal effect, criteria for extra-nuclear inheritance
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Mutation – genic, chromosomal and molecular levels
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Learn Introductory Genetics with Rahul

Non-disjunction

  • Non-disjunction refers to the chromosomes failing to separate correctly, resulting in gametes with one extra, or one missing, chromosome (aneuploidy)

 

The failure of chromosomes to separate may occur via:

  • Failure of homologues to separate in Anaphase I (resulting in four affected daughter cells)
  • Failure of sister chromatids to separate in Anaphase II (resulting in only two daughter cells being affected)
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